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KMID : 0379119980260040511
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Korean Journal of Mycology
1998 Volume.26 No. 4 p.511 ~ p.518
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Pharmacological Effects of Proteoglycans Extracted from Fruiting Bodies of Fomitella fraxinea
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황영수/Hwang, Young Soo
윤상홍/김창한/임재현/김양섭/조준형/Yoon, Sang Hong/Kim, Chang Han/Lim, Jae Hyeon/Kim, Yang Seop/Jo, Joon Hyeong
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Abstract
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Anti-complementary assay for immuno-stimulating polysaccharide screening, human tumor colony-forming assay for discovering anti-tumor drugs, and toxic assay against mouse were performed to examine pharmacological activities of polysaccharides extracted from fruiting bodies of Jang-soo mushroom (Fomitella fraxinea). Hot water (100℃, FF-1), 1% ammonium oxalate solution (80℃, FF-Ⅱ), and 5% sodium hydroxide solution (80℃, FF-Ⅲ) were used for extraction of three polysaccharides from fruiting bodies of it. Anti-complementary activity of FF-Ⅰ was more effective than the others. FF-Ⅰ was further fractionated into three groups of polysaccharide by DEAE-Sephadex A25 column chromatography (FF-NP, FF-AP1, and FF-AP2). FF-AP1 showed not only the highest anti-complementary activity but also the growth-inhibitory activity against Snu-1 (human stomach cancer cell) among 9 kinds of human tumor cell lines. But FF-AP2 exhibited its activity against Hep-2(larynx cancer) and KB(mouth epidermal cancer) cell lines at 500 ㎍/㎖ although its anti-complementary activity was lower than it of FF-AP1. When FF-Ⅰ was orally administrated to mice with dosage of 5000 ㎎/㎏, no remarkable changes were observed in viewpoint of tissue-pathology.
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